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Only one advertisement can run at a time on the client computer.
Therefore, if an advertisement is running on the client computer that could potentially take a while to complete (such as a full scan on a computer with a large hard disk), subsequent advertisements are processed after that advertisement completes.
Recently I had a client using System Center Endpoint Protection (SCEP) who was having issues with Definitions not being updated across their enterprise.
They also had issues with trying to manually update the definitions using the GUI.
I am going to start with the issues my client was having when manually trying to update the definitions by using the GUI and then go into why the client wasn’t getting updates from Config Mgr.